Patient Information Sheet for Acute Severe Ulcerative Colitis (ASUC) in Pregnancy
Managing Acute Severe Ulcerative Colitis During Pregnancy
What is Acute Severe Ulcerative Colitis (ASUC)?
Ulcerative colitis (UC) is a condition where your large intestine (colon) becomes inflamed. Sometimes, this inflammation becomes very severe and needs urgent treatment — this is called Acute Severe Ulcerative Colitis (ASUC).
Is it safe to treat ASUC during pregnancy?
Yes. It is very important to treat ASUC during pregnancy — both for your health and for your baby’s well-being. Uncontrolled inflammation is riskier than most treatments.
Doctors will choose medications that are proven to be safe in pregnancy.
How is ASUC treated during pregnancy?
- Corticosteroids (Steroids)
Given through the vein (IV) in the hospital, it help reduce the inflammation quickly.
Generally safe in pregnancy, especially after the first trimester.
- Supportive Care
Fluids, pain relief, rest, and special attention to your nutrition.
Blood tests and stool tests to monitor your condition.
- Rescue Medications (if steroids don’t work within 3–5 days):
Infliximab (a type of biologic medicine)
-Safe in pregnancy.
-May slightly increase risk of infections in newborn, especially if used late in pregnancy.
Cyclosporine (used in some cases)
-Used with caution and close monitoring.
-May be used short-term if infliximab is not an option.
What if medications don’t work?
If your condition doesn’t improve, surgery may be necessary. This is rare but can be lifesaving. Doctors may perform a procedure to remove the diseased part of your colon. It can be done safely during pregnancy if needed.
- How does it affect my baby?
Most treatments are safe for the baby.
Active inflammation is more harmful than the medicines.
Your baby may be monitored more closely during your pregnancy.
Can I breastfeed after treatment?
Yes! Most medications used in ASUC are safe for breastfeeding, including:
Steroids
5-ASA (mesalamine)
Infliximab
Azathioprine
Your doctor will guide you based on what you’re taking.
What happens after recovery?
Once you feel better:
You will be switched to maintenance medicines to keep the disease in remission.
It’s very important to continue medications even if you feel well, to avoid another flare.
Things to Remember :
Treating ASUC promptly is safe and necessary.
Your treatment plan is made with your baby in mind.
You are not alone — your doctors will support you throughout.
When to call your doctor immediately :
Severe abdominal pain
Bleeding that doesn’t stop
Vomiting or dehydration
Fever or chills
Feeling faint or dizzy
Follow-Up Is Important!
Keep all your appointments and always inform your obstetrician and gastroenterologist about any new symptoms.